Deepak Srivastava, MD
	Human cardiac disorders
	Email: dsrivastava@gladstone.ucsf.edu Website: Srivastava Lab
Selected Publications Complete Publications

Our laboratory focuses on understanding the causes of heart disease and on using knowledge of cardiac developmental pathways to devise novel therapeutic approaches for human cardiac disorders. Specifically, we study the molecular events regulating early and late developmental decisions that instruct progenitor cells to adopt a cardiac cell fate and subsequently fashion a functioning heart. We focus on transcriptional and post-transcriptional steps, particularly those involving microRNAs, during these steps. We also seek to identify the causes of human cardiovascular disease by applying modern genetic technologies for the study of complex traits such as congenital heart disease. By using a spectrum of approaches including mouse and human genetics, molecular and developmental biology, and biochemistry we hope to develop a broad understanding of the biology underlying cardiogenesis and cardiovascular disorders.

Selected Publications

Zhao Y, Ransom JF, Li A, Vedantham V, von Drehle M, Muth AN, Tsuchihashi T, McManus MT, Schwartz RJ, Srivastava D. (2007) Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell doi:10.1016/j.cell.2007.03.030.

Srivastava D, Ivey KN. (2006) Potential of stem cell-based therapies for heart disease. Nature 441:1097–1099.

Srivastava D. (2006) Making or breaking the heart: From lineage determination to morphogenesis. Cell 126:1037–1048.

Zhao Y, Samal E, Srivastava D. (2005) Serum response factor regulates a muscle-specific mircroRNA that targets Hand2 during cardiogenesis. Nature 436:214–220.

Information last updated April 2007