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The UCSF Program
in Craniofacial and Mesenchymal Biology
FACULTY
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Biomaterials and Calcified Tissues
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Currently my work is focused on structure- property relationships of calcified tissues, particularly enamel and dentin, and cementum, to improve our basic understanding of these biological materials with respect to their mechanical behavior, and demineralization processes associated with bonding procedures and pathology. We use a variety of complimentary techniques some of which are nearly unique to our group (x-ray tomographic microscopy; atomic force microscopy (AFM); and AFM-based nanoindentation) as well as other complimentary methods including wet SEM and x-ray microanalysis. We have pioneered several of these methods for the study of calcified tissues, and dentin in particular, and used the AFM to for the first demineralization rate studies, the first nanomechanical properties studies, and have obtained high resolution non-invasive images of caries and dentin that allows the study of the three dimensional structure of caries attack on tooth structure. This work helps define alteration in properties and structure with hydration state, mineral state, and variations induced by disease and physiological processes. This information is needed to develop a composite structural model of calcified tissues and to provide fundamental information needed for tissue engineering.
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Selected Publications
Schneider BT, Baumann MA, Watanabe LG, Marshall GW. (2000) Dentin Shear Bond Strength of Compomers and Composites. Dent Mater 16:15-19.
Marshall GW , Marshall SJ, Balooch M, Kinney JH. (2004) Evaluating Demineralization and Mechanical Properties of Human Dentin with AFM. Chapter 11 in Methods in Mol Biol 242:141-159.
Ho SP, Sulyanto RM, Marshall SJ, Marshall GW. (2005) The cementum-dentin junction also contains glycosaminoglycans and collagen fibrils. J Struct Biol 151:69-78.
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Osteoblast depositing
bone matrix |
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