Publications
The TGF-Beta Family
Cold Spring Harbor Monograph #50
edited by Rik Derynck and Kohei Miyazono
©2008 • 1,114 pp., illus., index • ISBN 978-087969752-5
224) LAMOUILLE, S. and DERYNCK, R. (2009) Oncogene and tumor suppressor: the two faces of SnoN. EMBO J., in press.
223) PISCOPO, D. M., JOHANSEN, E.B. and DERYNCK, R. (2009) Identification of the GATA factor TRPS1 as a repressor of the osteocalcin promoter. J. Biol. Chem., submitted 8/4/09, in press, 9/15/09 ref. JBC/2009/052316.
[ PubMed ]
222) WHARTON, K. and DERYNCK, R. (2009) TGF-β family signaling: novel insights in development and disease. Development 136, 3691-3697.
[ PubMed ]
221) KANG, J. S., LIU, C. and DERYNCK, R. (2009) New regulatory mechanisms of TGF-β receptor function. Trends in Cell Biology 19, 385-394. Review.
[ PubMed ]
220) WU, L., and DERYNCK, R. (2009) Essential role of TGF-β signaling in glucose-induced cell hypertrophy. Developmental Cell 17, 35-48. (subject of a Preview)
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219) LIU, C., XU, P. LAMOUILLE, S. XU, J. and DERYNCK R. (2009) TACE-mediated ectodomain shedding of the type I TGF-β receptor downregulates TGF-β signaling. Molecular Cell 35, 26-36.
[ PubMed ]
218) MOHAMMAD, K.S., CHEN, C., BALOOCH, G., STEBBINS, E., McKENNA, C.R., WALTON, H., NIEWOLNA, M., PENG, X.H., NGUYEN, D.H.N., IONOVA-MARTIN, S.S., BRACEY, J.W., HOGUE, W.R., WONG, D., RITCHIE, R.O., SUVA, L.J., DERYNCK, R., GUISE, T.A., and ALLISTON, T. (2009) Pharmacologic inhibition of the TGF-β type I receptor has anabolic and anti-catabolic effects. PLoS One, 4, e5275.
[ PubMed ]
217) XU, J., LAMOUILLE, S. and DERYNCK, R. (2009) TGF-beta-induced epithelial to mesenchymal transition. Cell Research 19, 156-172. Review.
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216) LIU, I.M., SCHILLING, S.H., KNOUSE, K.A., CHOY, L., DERYNCK, R., and WANG, X.-F.
(2009) TGF-beta-stimulated Smad1/5 phosphorylation functions as a pro-migratory TGF-beta switch in breast cancer cells. EMBO J. 28, 88-98.
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215) IMHOF, I., GASPER, W.J. and DERYNCK, R.
(2008) Association of the tetraspanin CD9 with transmembrane TGF-alpha confers
alterations in cell surface presentation of TGF-alpha and cytoskeletal organization. J. Cell Sci. 121, 2265-2274.
[ PubMed
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214) KANG, J.-S., SAUNIER, E., AKHURST, R.J. and DERYNCK, R.
(2008) The type I TGF-beta receptor is covalently modified and regulated by sumoylation. Nature Cell Biology 10, 654-664. (subject of News and Views)
[ PubMed
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213) ALLISTON, T., PIEK, E. and DERYNCK, R.
(2008) TGF-beta family signaling in skeletal development, maintenance and disease.
In The TGF-beta Family (R. Derynck and K. Miyazono, eds), Cold Spring Harbor Press, Chapter 22, 667-724. Review
212) DERYNCK, R., PIEK, E., SCHNEIDER, R.A., CHOY, L. and ALLISTON, T.
(2008) TGF-beta family signaling in mesenchymal differentiation. In The TGF-beta Family (R. Derynck and K.
Miyazono, eds), Cold Spring Harbor Press, Chapter 21, 613-666. Review
211) DERYNCK, R. and MIYAZONO, K. (2008) TGF-β and the TGF-β family. In “The TGF-β Family” (R. Derynck and K. Miyazono, eds), Cold Spring Harbor Press. Chapter 2, 29-44. Review.
210) DERYNCK R, AKHURST RJ.
(2007) Differentiation plasticity regulated by TGF-beta family proteins in development and disease.
Nat Cell Biol. 9(9): 1000-4.
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209) LEE MK, PARDOUX C, HALL MC, LEE PS, WARBURTON D, QING J, SMITH SM, DERYNCK R.
(2007) TGF-beta activates Erk MAP kinase signaling through direct phosphorylation of ShcA.
EMBO J. 26(17):3957-67.
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208) LAMOUILLE S, DERYNCK R.
(2007) Cell size and invasion in TGF-beta induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway.
J Cell Biol. 178(3):437-51.
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207) PEREZ-CASTRO C, PISCOPO D, NAKAGAWA T, DERYNCK R.
(2007) Cornichon regulates transport and secretion of TGF-alpha-related proteins in metazoan cells. J Cell Sci. 120(Pt 14): 2454-66.
[ PubMed
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206) WAN DC, AALAMI OO, WANG Z, NACAMULI RP, LORGET F, DERYNCK R.
(2006) Differential gene expression between juvenile and adult dura mater: a window
into what genes play a role in the regeneration of membranous bone. Plast Reconstr Surg. 118(4):851-61.
[ PubMed
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205) DERYNCK, R, CHOY, L., and ALLISTON, T. (2006) Smads in mesenchymal differentiation. In “Smad signal transduction” (ten Dijke, P. and Heldin, C.-H., eds), 93-112. Review.
204) HABIG M, SMOLA H, DOLE VS, DERYNCK R, PFISTER H, SMOLA-HESS S.
(2006) E7 proteins from high- and low-risk human papillomaviruses bind to TGF-beta-regulated
Smad proteins and inhibit their transcriptional activity. Arch Virol. 151 (10): 1961-72.
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203) BALOOCH, G., BALOOCH, M., NALLA, R.K., SCHILLING, S., FILVAROFF, E.H.,
MARSHALL, G.W., MARSHALL, S.J., RITCHIE, R.O., DERYNCK, R., and ALLISTON, T.
(2005) TGF-B signaling regulates the mechanical properties and composition
of bone matrix. Proc. Natl. Acad. Sci. USA 102, 18813-18818.
[ PDF 264 KB] [ PubMed
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202. MISHRA, L, DERYNCK, R. and MISHRA, B. (2005)
Transforming growth factor-B signaling in stem cells and cancer.
Science 310, 68-71. Review.
[ PDF 264 KB] [ PubMed
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201. FENG, X.-H. and DERYNCK, R. (2005)
Specificity and versatility in TGF-B signaling through Smads. Annu. Rev. Cell Dev. Biol. 21, 659-693. Review.
[ PDF 264 KB] [ PubMed
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200. QIN, B., LIU, C., SRINATH, H., LAM, S.S., CORREIA, J.J., DERYNCK, R. and LIN, K.
(2005) An activator-dependent conformational switch in CBP revealed by crystal structure
of the IRF-3/CBP complex. Structure 13, 1269-1277.
[ PDF 264 KB] [ PubMed
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199. KANG, J. S., ALLISTON, T., DELSTON, R. and DERYNCK, R.
(2005) Repression of Runx2 function by TGF-B through recruitment of
class II histone deacetylases by Smad3. EMBO J. 24, 2543-2555.
[ PDF 264 KB] [ PubMed
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198. NAKAGAWA, T., GUICHARD, A., PEREZ CASTRO, C., XIAO, Y., RIZEN, M., ZHANG, H.-Z., HU, D., BANG, A., HELMS, J., BIER, E. and DERYNCK, R.
(2005) Characterization of a human rhomboid homolog,p100hRho/RHBDF1, which interacts with
TGF-A family ligands. Developmental Dynamics 233, 1315-1331.
[ PDF 264 KB] [ PubMed
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197. ALLISTON, T., KO, T.C., CAO, Y., LIANG, Y.-Y., FENG, X.-H., CHANG, C. and DERYNCK, R.
(2005) Repression of BMP and activin-inducible transcription by Evi-1.
J. Biol. Chem. 280, 24227-24237.
[ PDF 264 KB] [ PubMed
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196. PARDOUX, C. and DERYNCK, R. (2004) JNK regulates expression
and autocrine signaling of TGF-bð1. Molecular Cell 15, 170-171.
[ PDF 264 KB] [ PubMed
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195. LIU, D., KANG, J.S. and DERYNCK, R. (2004) TGF-b-activated Smad3
represses MEF2-dependent transcription in myogenic differentiation. EMBO
J. 23, 1557-1566. [ PDF 264 KB] [ PubMed
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194. QING, J., LIU, C., CHOY, L., WU, R.-Y., PAGANO, J.S. and DERYNCK,
R. (2004) TGF-b/Smad3 signaling regulates IRF-7 function and transcriptional
activation of the interferon-b promoter. Molec. Cell. Biol. 24,
1411-1425. [ PDF 488 KB] [ PubMed
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193. QIN, B.Y., LIU, C., LAM, S.S., SRIMATH, H., DELSTON, R., CORREIA,
J.J., DERYNCK, R. and LIN, K. (2003) Crystal structure of IRF-3 transactivation
domain reveals mechanism of autoinhibition and virus-induced phospho-activation.
Nature Struct. Biol. 10, 913-921. [ PDF 2565 KB] [ PubMed
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192. DERYNCK, R. and ZHANG, Y.E. (2003) Smad-dependent and Smad-independent
pathways in TGF-b family signaling. Nature 425, 577-584.
[ PDF 559 KB] [ PubMed
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191. LEE, P.S., CHANG, C., LIU, D. and DERYNCK, R (2003) Sumoylation of
Smad4, the common Smad mediator of TGF-b family signaling. J. Biol.
Chem. 278, 27853-27863. [ PDF 437 KB] [ PubMed
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190. FAN, H., TURCK, C.W. and DERYNCK, R. (2003) Characterization of growth
factor-induced serine phosphorylation of tumor necrosis factor-a converting
enzyme (TACE) and of an alternatively translated polypeptide. J. Biol.
Chem. 278, 18617-18627. [ PDF 380 KB] [ PubMed
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189. CHOY, L. and DERYNCK, R. (2003) TGF-b inhibits adipocyte differentiation
by Smad3 interacting with CCAAT/Enhancer-binding protein (C/EBP) and repressing
C/EBP transactivation function. J. Biol. Chem. 278, 9609-9619.
[ PDF 712 KB] [ PubMed
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188. SKILLINGTON, J., CHOY, L., and DERYNCK, R. (2002) Bone morphogenetic
protein and retinoic acid signaling cooperate to induce osteoblast differentiation
of pre-adipocytes. J. Cell Biol. 159: 135-146.
[ PDF 640 KB] [ PubMed
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187. LI, C., ZHU, N.L., TAN, R.C., BALLARD, P.L., DERYNCK, R., and MINOO,
P. (2002) TGF-b inhibits pulmonary surfactant protein-B gene transcription
through SMAD3 interactions with NKX2.1 and HNF-3 transcription factors.
J Biol Chem. 277, 38399-38408. [ PDF 407 KB] [ PubMed
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186. ALLISTON, T. and DERYNCK, R. (2002) Interfering with bone remodeling
(News and Views). Nature 416, 686-687.
[ PDF, 328 KB ] [ PubMed]
185. QING, J. and DERYNCK, R. (2002) TGF-beta signaling and
Cancer. In The Cancer Handbook (M. Alison, Ed.) Nature
Publishing Group, Macmillan Publishers Ltd, 179-194.
[ PDF, 185 KB]
184. ROBERTS, A.B. and DERYNCK, R. (2001) Meeting Report:
Signaling Schemes for TGF-beta. Science STKE. 113pe43.
[ PDF, 768 KB ] [ PubMed
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STKE ]
183. LIU, D., BLACK, B.L., and DERYNCK, R. (2001) TGF-beta
inhibits muscle differentiation through functional repression of myogenic
transcription factors by Smad3. Genes Dev. 15, 2950-2966.
[ PDF, 476 KB ] [ PubMed
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182. AKHURST, R.J. and DERYNCK, R. (2001) TGF-beta signaling
in cancer: a two-edged sword. Trends Cell Biol. 11,
S44-S51.
[ PDF, 84 KB ] [ PubMed
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181. DERYNCK, R., AKHURST, R.J., AND BALMAIN, A. (2001)
TGF-beta signaling in tumor suppression and cancer progression.
Nature Genetics 29, 117-129 (Erratum Nature Genetics 29,
351)
[ PDF, 372 KB ] [ PubMed
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180. STOLL, S.W., KANSRA, S., PESCHIK, S., FRY, D.W., LEOPOLD, W.R.,
WIESEN, J.F., SIBILIA, M., ZHANG, T., WERB, Z., DERYNCK, R., WAGNER, E.F.,
and ELDER, J.T. (2001) Differential utilization and localization
of ErbB receptor tyrosine kinases in skin compared to normal and malignant
keratinocytes. Neoplasia 3, 339-350.
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179. ALLISTON, T., CHOY, L., DUCY, P., KARSENTY, G., and DERYNCK, R.
(2001) TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and
osteocalcin expression and inhibits osteoblast differentiation.
EMBO J. 20, 2254-2272.
[ PubMed
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178. FENG, X.-H., and DERYNCK, R. (2001) Mammalian two-hybrid
assays: analyzing protein-protein interactions in the TGF-beta signaling
pathway. In Two-hybrid systems: Methods and Protocols (ed.
P. McDonald) (series: Methods in Molecular Biology, vol. 177)
Humana Press. pp 221-239.
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177. ZHANG, Y., CHANG, C., GEHLING, D.J., HEMMATI-BRIVANLOU, A., and
DERYNCK, R. (2001) Regulation of Smad degradation and activity by
Smurf2, an E3 ubiquitin ligase. Proc. Natl. Acad. Sci.USA, 98,
974-979.
[ PubMed
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176. QING, J., ZHANG, Y. and DERYNCK, R. (2000) Structural
and functional characterization of the TGF-beta-induced Smad3/c-Jun transcriptional
cooperativity. J. Biol. Chem. 275, 38802-38812.
[ PubMed
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175. PATIL, S., WILDEY, G.M., BROWN, T.L., CHOY, L., DERYNCK, R., and
HOWE, P.H. (2000) Smad7 is induced by CD40 and protects WEHI-231
B lymphocytes from TGF-beta-induced growth inhibition and apoptosis.
J. Biol. Chem. 275, 38363-38370.
[ PubMed
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174. KUO, A., ZHONG, C., LANE, W.S. and DERYNCK, R. (2000) Transmembrane
transforming growth factor-alpha tethers to the PDZ-domain containing,
Golgi-membrane-associated protein p59/GRASP55. EMBO J. 19,
6427-6439.
[ PubMed
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173. FENG, X.-H., LIN, X., and DERYNCK, R. (2000) Smad2,
Smad3 and Smad4 cooperate with Sp1 to induce p15Ink4B expression in response
to TGF-beta. EMBO J. 19, 5178-5193.
[ PubMed
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172. ZHANG, Y. and DERYNCK, R (2000) Transcriptional regulation of the
TGF-beta-inducible, mouse germ-line Igalpha constant region gene by functional
cooperation of Smad, CREB and AML family members. J. Biol. Chem.
275, 16979-16985.
[ PubMed
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171. CHOY, L., SKILLINGTON, J. and DERYNCK, R. (2000) Roles
of autocrine TGF-beta receptor and Smad signaling in adipocyte differentiation.
J. Cell. Biol. 149, 667-681.
[ PubMed
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170. ALLISTON, T.N. and DERYNCK, R. (2000) Transforming growth
factor-beta in skeletal development and maintenance. In Skeletal
Growth Factors (ed. E. Canalis), Lippincott Williams and Wilkins,
Philadelphia, p. 233-249.
169. SHI, W., FAN, H., SHUM, L., and DERYNCK, R. (2000) The
tetraspanin CD9 associates with transmembrane TGF-alpha and regulates
TGF-alpha-induced EGF receptor activation and cell proliferation.
J. Cell Biol., 148, 591-601.
[ PubMed
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168. DERYNCK, R. (1999) Skeletal development in the zebrafish.
Nature Genetics 23, 379.
[ PDF, 144 KB ]
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167. FAN, H. and DERYNCK, R. (1999) Ectodomain shedding of
TGF-alpha and other transmembrane proteins is induced by receptor tyrosine
kinase activation and MAP kinase signaling cascades. EMBO J.
18, 6962-6972.
[ PDF, 548 KB ] [ PubMed
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166. FILVAROFF, E., ERLEBACHER, A., YE, J.-Q., GITELMAN, S.E., LOTZ,
J., HEILLMAN, M., and DERYNCK, R. (1999) Inhibition of TGF-beta
receptor signaling in osteoblasts leads to decreased bone remodeling and
increased trabecular bone mass. Development, 126, 4267-4279.
[ PubMed
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165. KORNBLUM, H. I., ZURCHER, S.D., WERB, Z., DERYNCK, R., and SEROOGY,
K. (1999) Multiple trophic actions of heparin-binding epidermal
growth factor (HB-EGF) in the central nervous system. Eur. J.
Neurosci., 11, 3236-3246.
[ PDF, 448 KB ] [ PubMed
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164. ZHANG, Y. and DERYNCK, R. (1999) Regulation of Smad
signaling by protein associations and signaling crosstalk. Trends
Cell Biol. 9, 274-279.
[ PDF, 136 KB ] [ PubMed
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163. MIETTINEN, P.J., CHIN, J.R., SHUM, L., SLAVKIN, H.C., SHULER, C.F.,
DERYNCK, R., and WERB, Z. (1999) EGF receptor function is
necessary for normal craniofacial development and palate closure.
Nature Genetics 22, 69-73.
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162. DERYNCK, R., ZHANG, Y., and FENG, X.-H. (1998) Smads: transcriptional
activators of TGF-beta responses. Cell 95, 737-740.
[ PDF, 112 KB ] [ PubMed
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161. CHOY, L., and DERYNCK, R. (1998) The type II transforming
growth factor-beta (TGF-beta) receptor-associated protein TRIP-1 acts
as a modulator of the TGF-beta response. J. Biol. Chem. 273,
31455-31462.
[ PubMed
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160. GRISWOLD-PRENNER, I., KAMIBAYASHI, C., MARUOKA, E.M., MUMBY, M.C.,
and DERYNCK, R. (1998) Physical and functional interactions
between type I transforming growth factor-beta receptors and Balpha, a
WD-40 repeat subunit of phosphatase 2A. Molec. Cell. Biol.
18, 6595-6604.
[ PubMed
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159. FILVAROFF, E. and DERYNCK, R. (1998) Bone remodeling:
A signalling system for osteoclast regulation. Current Biology
8, R679-R682.
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158. SEBASTIAN, J., RICHARDS, R.G., WALKER, M.P., WIESEN, J.F., WERB,
Z., DERYNCK, R., HOM, Y.K., CUNHA, G.R., and DIAUGUSTINE, R.P. (1998)
Activation and function of the epidermal growth factor receptor and erbB-2
during mammary gland morphogenesis. Cell Growth and Diferentiation
9, 777-785.
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157. KORNBLUM, H.I., HUSSAIN, R., WIESEN, J., MIETTINEN, P., ZURCHER,
S.D., CHOW, K., DERYNCK, R. and WERB, Z. (1998) Abnormal astrocyte
development and neuronal death in mice lacking the epidermal growth factor
receptor. J. Neurosci. Res. 53, 697-717.
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156. ZHANG, Y., FENG, X.-H., and DERYNCK, R. (1998) Smad3
and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription.
Nature 394, 909-913. (Erratum: Nature 396, 491)
[ PDF, 904 KB ] [ PubMed
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155. DERYNCK, R. and CHOY, L. (1998) Transforming growth
factor-beta and its receptors. In The Cytokine Handbook (A.
Thompson, ed.) Academic Press, Boston, San Diego, 3rd edition, pp.
593-636.
154. FENG, X.-H., ZHANG, Y., WU, R.-Y., and DERYNCK, R. (1998)
The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are
coactivators for Smad3 in TGF-beta-induced transcriptional activation.
Genes Dev. 12, 2153-2163.
[ PubMed
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153. ERLEBACHER, A., FILVAROFF, E.H., YE, J.-Q., and DERYNCK, R.
(1998) Osteoblastic responses to TGF-beta during bone remodeling.
Molec. Biol. Cell 9, 1903-1918.
[ PubMed
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152. DERYNCK, R. (1998) SMAD proteins and mammalian anatomy.
(News and Views) Nature 393, 737-739.
[ PDF, 277 KB ] [ PubMed
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151. GORSKA, A.E., JOSEPH, H., DERYNCK, R., MOSES, H.L., and SERRA, R.
(1998) Dominant-negative interference of the TGF-beta type II receptor
in the mammary gland results in alveolar hyperplasia and differentiation
in virgin mice. Cell Growth and Differentiation 9, 229-238.
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150. HOM. Y.K., YOUNG, P., WIESEN, J., MIETTINEN, P.J., DERYNCK, R.,
WERB, Z., and CUNHA, G. (1998) Uterine and vaginal organ growth
requires epidermal growth factor receptor (EGFR) signaling from stroma.
Endocrinology 139, 913-921.
[ PubMed
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149. VERLHAC, M.-H., CHEN, R.-H., HANACHI, P., HERSHEY, J.W.B., and DERYNCK,
R. (1997) Identification of partners of TIF34, a component
of the yeast eIF3 complex, required for cell proliferation and translation
initiation. EMBO J. 16, 6812-6822.
[ PubMed
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148. SERRA, R., JOHNSON, M., FILVAROFF, E.H., LABORDE, J., SHEHAN, D.,
DERYNCK, R., and MOSES, H.L. (1997) Expression of a cytoplasmically
truncated TGF-beta type II receptor in mouse skeletal tissue promotes
terminal chondrocyte differentiation and an osteoarthritis-like phenotype.
J. Cell Biol. 139, 541-552.
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147. CANDIA, A., WATABE, T., HAWLEY, S.H.B., ONICHTCHOUCK, D., ZHANG,
Y., DERYNCK, R., NIEHRS, C., and CHO, K. (1997) Cellular interpretation
of multiple TGF-beta signals: intracellular antagonism of activin/BVg1
and BMP-2/4 signaling mediated by Smads. Development 124,
4467-4480.
[ PubMed
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146. DERYNCK, R. and FENG, X.-H. (1997) TGF-beta receptor
signaling. BBA Reviews in Cancer 1333, F105-F150.
[ PDF, 774 KB ] [ PubMed
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145. MIETTINEN, P.J., WARBURTON, D., BU, D., ZHAO, J.-S., BERGER, J.E.,
MINOO, P., ALLEN, L., DOBBS, L., WERB, Z., and DERYNCK, R. (1997)
Impaired lung branching morphogenesis in the absence of functional EGF
receptor. Dev. Biol. 186, 224-236.
[ PubMed
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144. FENG, X.-H., and DERYNCK, R. (1997) A kinase subdomain
of the transforming growth factor-beta (TGF-beta) type I receptor determines
the TGF-beta intracellular signaling specificity. EMBO J.
16, 3912-3923.
[ PubMed
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143. LAWLER, S., FENG, X.-H., CHEN, R.-H., MARUOKA, E.M., TURCK, C.W.,
GRISWOLD-PRENNER, I., and DERYNCK, R. (1997) The type II transforming
growth factor-beta receptor autophosphorylates not only on serine and
threonine but also on tyrosine residues. J. Biol. Chem. 272,
14850-14859.
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142. WU, R.-Y., ZHANG, Y., FENG, X.-H., and DERYNCK, R. (1997)
Heteromeric and homomeric interactions correlate with signaling activity
and functional cooperativity of Smad3 and Smad4/DPC4. Molec.
Cell. Biol. 17, 2521-2528.
[ PubMed
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141. ZHANG, Y., MUSCI, T., and DERYNCK, R. (1997) The tumor
suppressor Smad 4/DPC 4 as a central mediator of Smad function.
Current Biology 7, 270-276.
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140. WANG, X.-J., GREENHALGH, D.A., BICKENBACH, J.R., JIANG, A., BUNDMAN,
D.S., KRIEG, T., DERYNCK, R., and ROOP, D.R. (1997) Expression
of a dominant negative type II transforming growth factor-beta receptor
in the epidermis of transgenic mice blocks TGF-beta-mediated growth inhibition.
Proc. Natl. Acad. Sci. USA 94, 2386-2391.
[ PubMed
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139. GITELMAN, S.E., KOBRIN, M., LEE, A., FET, V., LYONS, K., HOGAN,
B.L.M., and DERYNCK, R. (1997) Structure and sequence of the
mouse Bmp6 gene. Mammalian Genome 8, 212-214.
[ PDF, 84 KB ] [ PubMed
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138. SHUM, L., TURCK, C.W., and DERYNCK, R. (1996) Cysteines
153 and 154 of transmembrane transforming growth factor-alpha are palmitoylated
and mediate cytoplasmic protein association. J. Biol. Chem.
271, 28502-28508.
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137. DERYNCK, R., GELBART, W.M., HARLAND, R.M., HELDIN, C.-H., KERN,
S.E., MASSAGUE, J., MELTON, D.A., MLODZIK, M., PADGETT, R.W., ROBERTS,
A.B., SMITH, J., THOMSEN, G.H., VOGELSTEIN, B., and WANG, X.-F.
(1996) Nomenclature: vertebrate mediators of TGF-beta family
signals (note). Cell 87, 173.
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136. DERYNCK, R. and ZHANG, Y. (1996) Intracellular signaling:
The Mad way to do it. Current Biology 6, 1226-1229.
[ PubMed
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135. FILVAROFF, E.H., and DERYNCK, R. (1996) Induction of
myogenesis in mesenchymal cells by MyoD depends on their degree of differentiation.
Dev. Biol. 178, 459-469.
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134. ZHANG, Y., FENG, X.-H., WU, R.-Y., and DERYNCK, R. (1996)
Receptor-associated Mad homologues synergize as effectors of the TGF-beta
response. Nature 382, 168-172.
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133. FENG, X-H, and DERYNCK, R. (1996) Ligand-independent
activation of transforming growth factor-beta signaling pathways by heteromeric
cytoplasmic domains of TGF-beta receptors. J. Biol. Chem.
271, 13123-13129.
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132. SHUM, L., MIETTINEN, P.J., and DERYNCK, R. (1996) Transforming
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131. ERLEBACHER, A. and DERYNCK, R. (1996) Increased expression
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130. ARRICK, B.A., and DERYNCK, R. (1996) The biological
role of transforming growth factor-beta in cancer development. In
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129. DERYNCK, R., and WAGNER, E.F. (1995) Cell differentiation:
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128. FENG, X.-H., FILVAROFF, E.H., and DERYNCK, R. (1995)
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127. CHEN, R.-H., MIETTINEN, P.J., MARUOKA, E.M., CHOY, L. and DERYNCK,
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126. MIETTINEN, P.J., BERGER, J.E., MENESES, J., PHUNG, Y., PEDERSEN,
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125. GITELMAN, S.E., KIRK, M., YE, J.-Q., FILVAROFF, E.H., KAHN, A.,
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124. CHEN, R.-H., MOSES, H.L., MARUOKA, E.M., DERYNCK, R., and KAWABATA,
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123. ERLEBACHER, A., FILVAROFF, E.H., GITELMAN, S.E., and DERYNCK, R.
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122. GITELMAN, S.E., and DERYNCK, R. (1995) Transforming
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121. KHERADMAND, F., FOLKESSON, H.G., SHUM, L., DERYNCK, R., PYTELA,
R., and MATTHAY, M.A. (1994) Transforming growth factor-alpha
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120. DERYNCK, R., CHEN, R.-H., EBNER, R., FILVAROFF, E.H., and LAWLER,
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the Princess Takamatsu Cancer Research Fund: Molecular and cellular
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119. MIETTINEN, P.J., EBNER, R., LOPEZ, A.R., and DERYNCK, R. (1994)
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118. DERYNCK, R. (1994) TGF-beta receptor-mediated signaling.
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117. GITELMAN, S.E., KORBIN, M.S., YE, J.-Q, LOPEZ, A.R., LEE, A., and
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116. CHEN, R.-H. and DERYNCK, R. (1994) Homomeric interactions
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115. DERYNCK, R. (1994) Transforming growth factor-beta.
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114. FILVAROFF, E. H., EBNER, R., and DERYNCK, R. (1994)
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113. SHUM, L., REEVES, S.A., KUO, A.C., FROMER, E.S., and DERYNCK, R.
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112. BARECELLOS-HOFF, M.-H., DERYNCK, R., TSANG, M.L.-S., and WEATHERBEE,
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111. LAWLER, S., CANDIA, A.F., EBNER, R., LOPEZ, A.R., MOSES, H.L.,
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TGF-beta receptor has a coincident embryonic expression and binding preference
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110. NABEL, E.G., SHUM, L., POMPILI, V.J., YANG, Z.Y., SAN, H., SHU,
H.B., LIPTAY, S., GOLD, L., GORDON, R., DERYNCK, R., and NABEL, G.J.
(1993) Direct transfer of transforming growth factor beta1 gene
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109. EBNER, R., CHEN, R.-H, LAWLER, S., ZIONCHECK, T., and DERYNCK, R.
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108. CHANG, H.-L., GILLETT, N., FIGARI, I., LOPEZ, A.R., PALLADINO, M.A.,
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107. PITTELKOW, M.R., COOK, P.W., SHIPLEY, G.D., DERYNCK, R., and COFFEY,
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106. EBNER, R., CHEN, R.-H., SHUM, L., LAWLER, S., ZIONCHECK, T., LOPEZ,
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105. CHEN, R.-H., EBNER, R. and DERYNCK, R. (1993) Inactivation
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104. GAZIT, D., EBNER, R., KAHN, A.J., and DERYNCK, R. (1993)
Modulation of expression and cell surface binding of members of the transforming
growth factor-beta superfamily during retinoic acid-induced osteoblastic
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103. ARRICK, B.A., and DERYNCK, R. (1993) Growth regulation
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102. STREULI, C.H., SCHMIDHAUSER, C., KOBRIN, M., BISSELL, M.J., and
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101. ARRICK, B.A., LOPEZ, A.R., ELFMAN, F., EBNER,
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100. LOPEZ, A.R., COOK, J., DEININGER, P.L., and DERYNCK, R. (1992)
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99. DERYNCK, R. (1992) The physiology of transforming growth
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98. LYONS, R.M., MILLER, D.A., GRAYCAR, J.L., MOSES, H.L, and DERYNCK,
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97. ARRICK, B.A., LEE, A., GRENDELL, R.L., and DERYNCK, R. (1991)
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96. EBNER, R., and DERYNCK, R. (1991) Epidermal growth factor
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95. BALENTIEN, E., MUSSON, B.E., SHATTUCK, R.L., DERYNCK, R., and RICHMOND,
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94. THOMAS, H.G., HAN, J.H., BALENTIEN, E., DERYNCK, R., BORDONI, R.,
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93. LUCAS, C., BRINGMAN, T. S., and DERYNCK, R. (1991) Generation
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92. DERYNCK, R. (1991) Transforming growth factor-beta. In
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90. BALENTIEN, E., HAN, J. H., THOMAS, H. G., WEN, D., SAMANTHA, A. K.,
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89. DING, A., NATHAN, C., GRAYCAR, J., DERYNCK, R., STUEHR, D. J., and
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87. MILLER, D. A., PELTON, R. W., DERYNCK, R., and MOSES, H. L.
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85. ARRICK, B.A., KORC, M., and DERYNCK, R. (1990) Differential
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84. LYONS, K.M., PELTON, R.W., GRAYCAR, J.L., DERYNCK, R., and HOGAN,
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83. GRAYCAR, J. L., MILLER, D.A., ARRICK, B.A., LYONS, R.M., MOSES, H.L.,
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82. MILLER, D.A., LEE, A., MATSUI, Y., CHEN, E.Y., MOSES , H.L., and
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81. BASCOM, C.C., WOLFSHOHL, J.R., COFFEY, R.J., MADISEN, L., WEBB,N.R.,
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regulation of transforming growth factor beta1, beta2 and beta3 mRNA expression
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80. MILLER, D.A., LEE, A., PELTON, R.W., CHEN, E.Y., MOSES, H.L., and
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79. WEN, D., ROWLAND, A., and DERYNCK, R. (1989) Expression
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78. DERYNCK, R. Transforming growth factors-alpha and-beta and
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77. LYONS, K., GRAYCAR,J.L., LINDQUIST, P.B., LEE, A., CHEN, E. Y., HOGAN,
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to Xenopus vg-1, is a member of the transforming growth factor-beta
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76. DERYNCK, R., LINDQUIST, P.B., BRINGMAN, T.S., WILCOX, J.N., ELDER,
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gene in tumor cells and normal cells. Cancer Cells Vol. 7
(Cold Spring Harbor Laboratory), 297-301.
75. SHANKAR, V., CIARDIELLO, F., KIM, N., DERYNCK, R., LISCIA, D.S.,
MERLO, G., LANGTON, B.C., SHEER, D., CALLAHAN, R., BASSIN, R.H., LIPPMAN,
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74. PITTELKOW, M.R., LINDQUIST, P.B., ABRAHAM, R., GRAVES-DEAL, R.,
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73. BRACHMANN, R., LINDQUIST, P.B., NAGASHIMA, M., KOHR,W., LIPARI,
T., NAPIER, M., and DERYNCK, R. (1989) Transmembrane TGF-alpha
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72. OQUENDO, P., ALBERTA, J., WEN, D., GRAYCAR, J.L., DERYNCK, R., and
STILES, C.D. (1989) The platelet derived growth factor-inducible
KC gene encodes a secretory protein related to platelet alpha-granule
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71. ELDER, J.T., FISHER, G.J., LINDQUIST, P.B., BENNETT, G.L., PITTELKOW,
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70. DERYNCK, R., LINDQUIST, P.B., TAMM, J., WEN, D., GRAYCAR, J., LEE,
A., and CHEN, E.Y. (1988) Transforming growth factor-beta:
a family of structurally related factors. Progress in Endocrinology
1988 (eds. H. Imura, K. Shizume, and S. Yoshida), Vol.1, 509-516.
69. BARTON, D.E., FOELLMER, B.E., DU, J., TAMM, J., DERYNCK, R., and
FRANCKE, U. (1988) Chromosomal mapping of genes for transforming
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68. JAKOBOVITS, E.B., SCHLOKAT, U., VANNICE, J.L., DERYNCK, R., and LEVINSON,
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initiation from a single site in the absence of a TATA sequence.
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67. DERYNCK, R., LINDQUIST, P.B., LEE., A., WEN, D., TAMM, J., GRAYCAR,
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66. DERYNCK, R. (1988) Transforming growth factor-alpha.
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65. FINZI, E., KILKENNY, A., STRICKLAND, J.E., BALASCHAK, M., BRINGMAN,
T.S., DERYNCK, R., AARONSON, S., and YUSPA, S.H. (1988) TGF-alphastimulates
growth of skin papillomas by autocrine and paracrine mechanisms but does
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64. RICHMOND, A., BALENTIEN, E., THOMAS H.G., FLAGGS, G., BARTON, D.E.,
SPIESS, J., BORDONI, R., FRANCKE, U., and DERYNCK, R. (1988)
Molecular characterization and chromosomal mapping of melanoma growth
stimulatory activity, a growth factor structurally related to beta-thromboglobulin.
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63. WILCOX, J.N., and DERYNCK, R. (1988) Developmental expression
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62. DERYNCK, R. (1988) Expression of transforming
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61. DERYNCK, R. (1988) Transforming growth factor-alpha:
structure and biological activities. In Growth Factors, Tumor
Promoters and Cancer Genes, (Colburn, N.H., Moses, H.L., and Stanbridge,
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60. WILCOX, J.N., and DERYNCK, R. (1988) Localization of
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59. LIU, S.C., SANFILIPPO, B., PERROTEAU, I., DERYNCK, R., SALOMON,
D.S., and KIDWELL, W.R. (1987) Expression of transforming
growth factor-alpha (TGF-alpha) in differentiated rat mammary tumors:
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58. GUTIERREZ, G., MUNDY, G.R., DERYNCK, R., HEWLETT, E.L., and KATZ,
M.S. (1987) Inihibition of parathyroid hormone-responsive
adenylate cyclase in clonal osteoblast-like cells by transforming growth
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57. SMITH, J.J., DERYNCK, R., and KORC, M. (1987) Production
of transforming growth factor-alpha in human pancreatic cancer cells:
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56. COFFEY, R.J., DERYNCK, R., WILCOX, J.N., BRINGMAN, T.S., GOUSTIN,
A.S., MOSES, H.L., and PITTELKOW, M.R. (1987) Production and
auto-induction of transforming growth factor-alpha in human keratinocytes.
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55. DERYNCK, R., WINKLER, M.E., and SCHREIBER, A.B. (1987)
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54. DERYNCK, R., and RHEE, L. (1987) Sequence of the porcine
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53. DERYNCK, R., RHEE, L., CHEN, E.Y., and VAN TILBURG, A. (1987)
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52. GAN, B.S., HOLLENBERG, M.D., MacCANNELL, K.L., LEDERIS, K., WINKLER,
M.E., and DERYNCK, R. (1987) Distinct vascular actions of
epidermal growth factor-urogastrone and transforming growth factor-alpha.
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51. FINZI, E., FLEMING, T., SEGATTO, O., PENNIGTON, C., BRINGMAN, T.S.,
DERYNCK, R., and AARONSON, S.A. (1987) The human transforming
growth factor-alpha coding sequence is not a direct acting oncogene when
overexpressed in NIH/3T3 cells. Proc. Natl. Acad. Sci. USA
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50. BRINGMAN, T.S., LINDQUIST, P.B., and DERYNCK, R. (1987)
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49. KNABBE, C., LIPPMAN, M.E., WAKEFIELD, L.E., FLANDERS, K.L., KASID,
A., DERYNCK, R., and DICKSON, R.B. (1987) Evidence that transforming
growth factor-beta is a hormonally regulated negative growth factor in
human breast cancer cells. Cell 48, 417-428.
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48. DERYNCK, R., GOEDDEL, D.V., ULLRICH, A., GUTTERMAN, J.U., WILLIAMS,
R.D., BRINGMAN, T.S., and BERGER, W.H. (1987) Synthesis of
messenger RNAs for transforming growth factors-alpha and -betaand the
epidermal growth factor receptor by human tumors. Cancer Res.
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47. SALOMON, D.S., PERROTEAU, I., KIDWELL, W.R., TAM, J., and DERYNCK,
R. (1987) Loss of growth responsiveness to epidermal
growth factor and enhanced production of alpha-transforming growth factor
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46. DERYNCK, R. (1987) Structure of transforming growth factors-alpha
and -beta and their precursors. In Oncogenes, genes and growth factors,
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45. DERYNCK, R. (1986) Transforming growth factor-alpha:
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